Clinical feasibility study of transcatheter edge-to-edge mitral valve repair in dogs with the canine V-Clamp device
Clinical feasibility study of transcatheter edge-to-edge mitral valve repair in dogs with the canine V-Clamp device
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ObjectiveTo determine procedural feasibility, safety, and short-term efficacy in dogs with severe degenerative mitral regurgitation (MR) undergoing transcatheter edge-to-edge repair (TEER) with a canine-specific device.DesignProspective, single-arm (uncontrolled), single-institution clinical feasibility study.AnimalsFifty client-owned dogs with severe degenerative MR operated over a 28-month period.MethodsTEER was performed using the canine mitral V-Clamp via a transapical approach using transesophageal echocardiographic and fluoroscopic guidance.Indices of MR severity were determined by echocardiography the day before and 2 to 3 days after the procedure.
ResultsProcedural feasibility was 96% based on delivery of at least one device in 48 of 50 dogs.There were no procedural deaths.Procedural safety was 96% based on survival to hospital discharge in 48 of 50 dogs.Euthanasia in 2 SHOPPING CENTERS: UMA RELAÇÃO ENTRE OS ATRIBUTOS DE ESCOLHA PELOS CONSUMIDORES VERSUS OS ATRIBUTOS VALORIZADOS PELOS GERENTES dogs prior to hospital discharge was due to damage of the mitral valve and worsened MR after the procedure.Device-related adverse event rate was 6.
3% based on 3 events (single-leaflet device detachment, locking failure, locking failure with device embolization) in 59 implanted devices.All three events were nonfatal and successfully treated with a second device.Median regurgitant volume (mL/kg) decreased (p < 0.001) from 2.3 [1.
9, 3.1] to 1.1 [0.3, 1.8].
Median effective regurgitant orifice area (cm2/m2) decreased (p < 0.001) from 0.60 [0.40, 0.80] to 0.
25 [0.10, 0.50].Conclusion and clinical importanceInitial feasibility results support continued development of TEER as a procedurally feasible, relatively low-risk, A systematic review of the interrelations of urban form and mode choice in African cities and low morbidity treatment for degenerative MR in dogs.Operator experience and case selection are likely to be important components of success of this technique.
Evidence of short-term efficacy is promising but needs to be verified with longer-term follow up.